Live attenuated

Inactivated

Vector

DNA

RNA

Weakened

Heat

Chemicals

Uses carrier

Plasmids, antigenic proteins

Antigenic proteins

Strong response

Safer

Strong response

No risk of infection

No risk of infection or integration

Caution with immuno-compromized

Require booster

Less useful if immune to carrier

Risk tolerance to antigen, risk integration genome

May trigger unintended immune response

MMR, chickenpox

Polio

Ebola

Indian immunologicals

Sinovac, Sinopharma

AstraZeneca, Janssen (modified adenovirus)

Misc

Moderna, Pfizer

Beta-proprolactone to bind to DNA, virus cannot longer replicate. Spike proteins are unaffected, so can be recognized by immune system. Aluminum-based compound as adjuvant to stimulate the immune system to boost its response to a vaccine.

Normal freezers, no need foor super-cold transportation network